Rethinking regeneration: role of nerve-derived cells in tissue homeostasis and injury response

The paradigm of adult tissue regeneration based on adult "tissue resident" stem cells differentiating into committed precursors to repair/replace the damaged area is currently being reformulated in different systems, as alternative explanations are beginning to emerge. Rather than being a cell intrinsic property, stemness may be dictated instead by the pericellular niche (cell-cell, cell-ECM and other microenvironmental inputs and contacts)...