Magnetic fields have emerged as a powerful tool in biomedical applications, offering a non-invasive,remotely controllable approach for precise spatial and temporal modulation in targeted therapies.Biological tissue is largely transparent to magnetic energy, allowing magnetic fields to pass throughwithout significant absorption or distortion.

Anisotropic magnetic nanoparticles, such as magnetite nanodiscs, possess unique intrinsic properties,including the ability to act both as nanoscale ‘heaters’ and as ‘torquers’ by leveraging either hystereticlosses, under kHz frequencies or transitions from vortex to in-plane magnetization under Hzfrequencies. 

This seminar will explore the design, synthesis, and characterization of hybrid magnetic stimuli-responsive nanostructures, achieved by integrating magnetite nanodiscs with advanced polymericcoatings. These hybrid systems leverage the unique bimodal functionality of MNDs in combination withfunctional polymeric materials to enable controlled nanoscale heating, torque generation, andtargeted delivery mechanisms. 

Special emphasis will be placed on their potential for neuronal modulation, leveraging thermo-responsive coatings to facilitate genetic modulation via viral vector transport, and piezoelectriccoatings to convert torques into electrical signals for the remote control of mechanosensory neurons.