Life, and the Darwinian evolution it is part of, hinges on replication and the resulting exponential growth. The same replication and exponential growth have powered the biotechnological revolution. For example, PCR exponentially amplifies DNA, which has led to groundbreaking discoveries such as directed evolution, in vitro selection, and unprecedented analytical sensitivity. Both biological replication and PCR require separating double-stranded DNA so it can serve as a template for its own copy. Once the template is bound to the copy, however, strand separation becomes thermodynamically unfavorable, which prevents new DNA fragments from binding (product inhibition). Product inhibition affects DNA, peptides, and non-biological replicators alike, and while environmental cycling (like PCR's thermal cycling) can circumvent it, sustained, isothermal exponential growth remains an open challenge. In today's talk, I'll discuss how we can use chemical energy to control supramolecular chemistry and drive enzyme-free self-replication without product inhibition, opening a new route to understanding how chemistry gave rise to biology.