Resting-state functional magnetic resonance imaging (rsfMRI) is increasingly used to unravel the functional neuronal networks in health and disease. In particular, this technique of simultaneously probing the whole brain has found high interest in monitoring brain wide effects of cerebral disease and in evaluating therapeutic strategies. We develop rs-fMRI methods in animal models to investigate the susceptibility of different brain regions to age-related functional changes and to compare the brain changes associated with healthy aging, pathological aging (such as Alzheimer's disease or dementia), and accelerated aging. This information is helping us to better understand the underlying mechanisms of different aging processes.