The project "DeDNAed" intends to develop a novel, innovative biosensing platform whose advantages and benefits are in terms of sensitivity, versatility and being ultrafast by an optical approach. Our platform will be based on the assembly and integration of sensing elements (transducer and bioreceptor) by DNA origami. The DNA origami will serve as a “nano breadboard” in order to precisely control the position of these elements and thus the sensor architecture at the nanometer scale.

CIC biomaGUNE’s role in the project is the design, synthesis, and characterization of different sensing biorecognition elements (antibodies and DNA aptamers) in pure state and modified with metallic and semiconductor atomic clusters. We will also design, synthesize, and provide metallic nanoparticles of different size and shape as amplifiers of optical read out signals.

DeDNAed started on March 1st, 2021 with a duration of 36 months.