Recent progress in bottom-up wet-chemical synthesis of gold nanoparticles has created remarkable opportunities to produce nanoparticles with well-defined chiral shapes and strong chiroptical activities. This perspective focuses on the seed-mediated synthesis of chiral gold nanorods as a convenient case of chiral morphogenesis. Growth mechanisms, chirality measures, and advanced electron microscopy characterization techniques are discussed, aiming to connect chiral morphologies, growth conditions, and optical behavior.