- Multi-parametric high- resolution imaging of white matter
- In vitro and in vivo quantification of myelin
- Nanomaterials for theranostics on demyelination processes
In the elderly, the total length of myelinated axons is reduced by 30-45%, primarily affecting fibers that myelinate later in development. Age-related myelin breakdown has a negative impact on cognitive performance. We aim to develop a set of non-invasive imaging tools and protocols for the study of the age-associated myelin breakdown process. IN this research line we work on the definition of robust imaging biomarkers that allow us to quantify myelin content and status in the full brain, to provide precise information of brain integrity and evolution during aging. Although postmortem histopathological methods remains as the gold standard for the characterization of myelin in the brain, advances in imaging have allow us to image changes in vivo, using MRI.